Figure 5.

Transmission electron microscopy images of murine retinas. (a, b) Retinas of two different wild-type control mice. (c, d) Retinas of two Cyp4v3^−/− mice. The presence of osmium increases the electron density of lipid-containing structures, so lipid-filled vacuoles appear as scattered solitary foci or confluent black globular structures. In one sample from a Cyp4v3^−/− albino mouse, the pigment normally present within the pigment epithelium was missing, but other structures were the same. Ch, choroid; M, melanin pigment granule; N, nucleus; Ph, photoreceptors; RPE, retinal pigmented epithelium.