Methods	Open, randomized 2×2 factorial design
Participants	Men and women, mean age 40 years N=219
Interventions	Diet advice and supervised endurance exercise programme Duration 1 year
Outcomes	No clinical event outcomes reported Systolic blood pressure, diastolic blood pressure, blood cholesterol Also measured haemostatic factors, BMI, body weight, waist hip ratio, aerobic capacity, thiocyanate, triglycerides, HDL/LDL cholesterol
Notes	Comparison used in this review is between the control group (N=43) and the diet+exercise group(N=65). Diet only and exercise only groups were not considered as single interventions