Methods | Primary care screening Randomisation of individuals in 2×3 factorial design |
Participants | People with at least two risk factors in addition to moderately raised blood cholesterol Men and women, mean age 49 years (30-59) N=681 |
Interventions | Factor 1: Counselling on health problems and risk factor management, food purchasing, exercise vs. usual care Factor 2: Pravastatin vs. placebo vs control without drug Duration 1 year |
Outcomes | Total mortality and CHD mortality Systolic blood pressure, diastolic blood pressure, blood cholesterol, smoking prevalence, exercise score |
Notes | At one year counselling intervention main effects showed lower blood cholesterol and lower Framingham risk factor scores compared with groups not receiving counselling intervention. No significant differences in blood pressures, smoking prevalence, or exercise score |