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. Author manuscript; available in PMC: 2014 Sep 10.
Published in final edited form as: Cochrane Database Syst Rev. 2006 Oct 18;(4):CD001561. doi: 10.1002/14651858.CD001561.pub2
Methods Primary care screening
Randomisation of individuals in 2×3 factorial design
Participants People with at least two risk factors in addition to moderately raised blood cholesterol
Men and women, mean age 49 years (30-59)
N=681
Interventions Factor 1: Counselling on health problems and risk factor management, food purchasing, exercise vs. usual care
Factor 2: Pravastatin vs. placebo vs control without drug
Duration 1 year
Outcomes Total mortality and CHD mortality
Systolic blood pressure, diastolic blood pressure, blood cholesterol, smoking prevalence, exercise score
Notes At one year counselling intervention main effects showed lower blood cholesterol and lower Framingham risk factor scores compared with groups not receiving counselling intervention. No significant differences in blood pressures, smoking prevalence, or exercise score