Skip to main content
. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Neurooncol. 2014 May 4;119(1):27–35. doi: 10.1007/s11060-014-1458-6

Figure5.

Figure5

Kaplan-Meier survival plot analysis of human patients overexpressing the ESPL1 gene encoding Separase protein shows a significantly reduced survival corresponding to Separase expression (A, NCI Rembrandt data set). ESPL1 is also found to be significantly overexpressed in several subsets of glioblastoma (B, TCGA data set), including classical, proneural G-CIMP (GcmP), Mesenchymal (Mesench), Neural and Proliferative (Prolif) compared to normal brain. ESPL1overexpression correlates with increased IDH1 mutation status in GBMs (p<0.05) while IDH1 is not significantly differentially expressed in any GBM subtype (mRNA levels of mutated and normal IDH1 remain the same).(C, TCGA and REMBRANDT data set).