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. 2014 Sep 10;9(9):e106653. doi: 10.1371/journal.pone.0106653

Figure 3. Time course of latanoprost release from senofilcon A in the three in vitro models.

Figure 3

Lenses were soaked for 24 hours in drug solution (Inline graphic) and then overlayed on the model for 24 hours. Aliquots were taken at specific times from the lower compartment and concentrations were measured using EIA. Daily dose line represents the amount of the administered latanoprost for a glaucoma patient [46]. No-Cell Model: Cell culture inserts (PET membrane) without cells, Monolayer Model: PET insert with a monolayer of human corneal epithelial cells, Multilayer Model: PET insert with a multilayer of human corneal epithelial cells (stratified culture). *Significantly different from in vitro models with cells Inline graphic. (n = 6 Mean Inline graphic SD).