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. 2014 Sep 10;9(9):e106653. doi: 10.1371/journal.pone.0106653

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© 2014 Mohammadi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Lenses were soaked for 24 hours in drug solution () and then overlayed on the model for 24 hours. Aliquots were taken at specific times from the lower compartment and concentrations were measured using EIA. Daily dose line represents the amount of the administered latanoprost for a glaucoma patient [46]. No-Cell Model: Cell culture inserts (PET membrane) without cells, Monolayer Model: PET insert with a monolayer of human corneal epithelial cells, Multilayer Model: PET insert with a multilayer of human corneal epithelial cells (stratified culture). *Significantly different from in vitro models with cells . (n = 6 Mean SD).

Inline graphic — Lenses were soaked for 24 hours in drug solution () and then overlayed on the model for 24 hours. Aliquots were taken at specific times from the lower compartment and concentrations were measured using EIA. Daily dose line represents the amount of the administered latanoprost for a glaucoma patient [46]. No-Cell Model: Cell culture inserts (PET membrane) without cells, Monolayer Model: PET insert with a monolayer of human corneal epithelial cells, Multilayer Model: PET insert with a multilayer of human corneal epithelial cells (stratified culture). *Significantly different from in vitro models with cells . (n = 6 Mean SD).