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. 2014 Sep 10;9(9):e105406. doi: 10.1371/journal.pone.0105406

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© 2014 Zhu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Desired cellular output; (B) Imposed externally controlled mechanotactic signal; (C) Measured cellular displacement in the direction for 3 distinct cells with a different color for each cell. The observed small differences in cellular response between the three cells are rooted in the biological variability of this sample. The initial positions of the 3 cells have been arbitrarily shifted to circumvent the overlapping of the plots; (D) Instantaneous snapshot of the 3 cells in the observation area at instant s. The double red arrow indicates the mechanostimulus direction. See SI Movie S1 for the complete migration of these 3 cells. The calcium concentration is 3 mM and the complete duration of the cellular course is 2600 seconds or 43 minutes. Cells are crawling over a plastic hydrophobic surface.

Inline graphic — (A) Desired cellular output; (B) Imposed externally controlled mechanotactic signal; (C) Measured cellular displacement in the direction for 3 distinct cells with a different color for each cell. The observed small differences in cellular response between the three cells are rooted in the biological variability of this sample. The initial positions of the 3 cells have been arbitrarily shifted to circumvent the overlapping of the plots; (D) Instantaneous snapshot of the 3 cells in the observation area at instant s. The double red arrow indicates the mechanostimulus direction. See SI Movie S1 for the complete migration of these 3 cells. The calcium concentration is 3 mM and the complete duration of the cellular course is 2600 seconds or 43 minutes. Cells are crawling over a plastic hydrophobic surface.