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. 2014 Sep 10;9(8):e106806. doi: 10.1371/journal.pone.0106806

Table 9. Population-based cohort studies reporting mid- and long-term survival for children with congenital heart defects.

Lead author, publication year Region/State, Country Period Study population (n) Method/Design; Outcome measure Period of follow-up Survival/mortality
Morris, 1991 [29] Oregon, US Operated 1958–1989 Children aged <18 years (n = 2,701) Retrospective review of paediatric cardiac procedures (for 8 CHD types); Death after surgery Up to 25 years after surgery Varying by CHD: 64% survival at 15 years after surgery (transposition) to 98% survival (atrial septal defect)
Samanek, 1992 [28] Bohemia, Czech Republic Diagnosed 1952–1979 Deaths aged ≤15 years (n = 946) Retrospective review of death registrations; Death ≤15 years old Up to 16 years of age 71% survival at 1 year of age; 67% survival at 15 years of age
Meberg, 2000 [31] Vestfold County, Norway Diagnosed 1982–1996 Children diagnosed clinically or at post-mortem (n = 360) Prospective follow-up after diagnosis; Death ≤18 years old Mean 9.5 years (range 3–18 years) Overall 12% mortality at end of follow-up
Nieminen, 2001 [10] Finland Operated 1953–1989 Children aged <15 years old at surgery (n = 6,461) Retrospective review of paediatric cardiac procedures (all CHDs); Death after surgery Mean 22 years after surgery (range 9–45 years) Overall 7% surgical mortality; 78% survival at 45 years after surgery
Wren, 2001 [9] Northern Region, UK Born 1985–1994 Children diagnosed clinically or at post-mortem (n = 1,942) Prospective follow-up from birth/diagnosis; Death ≤15 years old Up to 16 years of age 82% survival at 1 year of age; Predicted 78% survival to 16 years of age
Moons, 2009 [32] Belgium Born 2002 Children diagnosed clinically (n = 921) Prospective follow-up from birth/diagnosis; Death ≤5 years old Up to 5 years of age 96% survival at 5 years of age
Larsen, 2011 [30] Western Region, Denmark Operated 1996–2002 Children operated for CHD (n = 801) Prospective follow-up after cardiac surgery; Death after surgery Median 8.2 years after surgery (range 6–12 years) 86% survival at 8.2 years after surgery