Table 3. Univariate and multivariate Cox proportional analysis regarding overall survival.

Parameter	Univariate analysis		Multivariate analysis
	HR (95% Cl)	p-value	HR (95% Cl)	p-value
Age at operation (yrs.)
<60	1 (referent)		1 (referent)
≥60	2.08 (1.30–3.30)	0.002	1.77 (1.10–2.85)	0.019
Gender
Female	1 (referent)		1 (referent)
Male	0.94 (0.67–1.32)	0.718	0.83 (0.58–1.17)	0.281
Tumor depth
Superficial	1 (referent)		1 (referent)
Deep	1.09 (0.75–1.59)	0.648	0.99 (0.65–1.50)	0.956
Tumor grade
G1+G2	1 (referent)		1 (referent)
G3	2.92 (1.95–4.35)	<0.001	2.55 (1.67–3.89)	<0.001
Tumor size
<5 cm	1 (referent)		1 (referent)
5–10 cm	1.21 (0.96–1.51)	0.103	1.14 (0.88–1.47)	0.320
≥10 cm
Hb level
<13 g/dl in males and
>12 g/dl in females	1 (referent)		1 (referent)
≥13 g/dl in males and	0.26 (0.18–0.37)	<0.001	0.34 (0.23–0.51)	<0.001
≥12 g/dl in females