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. 2014 Sep 10;9(9):e107295. doi: 10.1371/journal.pone.0107295

Table 1. Specificity of An. gambiae SGH hemagglutinating activity.

Ligand Inhibitory concentration*
1. Sulfated polysacharides
Dextran sulfate 500,000 <3.715 pM
Dextran sulfate 50,000 <37.15 pM
Fucoidan 470 pM
Heparin Grade II 78 µg/ml
Condrotin sulfate A NI up to 1.25 mM#
Condrotin sulfate C NI up to 1.25 mM
Heparan sulfate NI up to 0.25 mM
Keratan sulfate NI up to 0.25 mM
Dextran 500,000 NI up to 125 µM
Dextran sulfate 5,000 NI up to 1.25 mM
2. Proteins
Laminin 18 nM
Heparan Sulphate Proteoglycan 93 nM
Glycophorin NI up to 0.5 mg/ml
Asialoglycophorin NI up to 5 mg/ml
Orosomucoid NI up to 5 mg/ml
Fetuin NI up to 5 mg/ml
3. Sialic acid-containing glycans
Sialic acid 6.25 mM
3′-sialyl Lewis X 0.3125 mM
3′-sialyl Lewis A NI up to 1.25 mM
3′-sulfated Lewis A 0.625 mM
3′-sialyl lactose 0.156 mM
6′-sialyl lactose 0.078 mM
Tetrasacharide A NI up to 2.5 mM
Tetrasacharide B NI up to 2.5 mM
Tetrasacharide C NI up to 2.5 mM
Di-sialyl lactose-tetraose NI up to 2.5 mM
3′-sialyl fucosil lactose NI up to 2.5 mM
4. Gangliosides
Monosialoganglioside (GM3) 0.312 mM
Disialoganglioside (GD1a) 0.312 mM
Disialoganglioside (GD1b) 0.625 mM
Trisialoganglioside (GT1B) 0.156 mM
Tetrasialoganglioside (GM1) 0.625 mM
Tetrasialoganglioside (GQ1B) 0.2 mM
5. Simple sugars
Maltose NI up to 25 mM
Galactose NI up to 25 mM
Trehalose NI up to 25 mM
Manose NI up to 25 mM
Glicose NI up to 25 mM
N-acetil-galactosamine NI up to 25 mM

*Inhibitory concentration; minimal concentration promoting inhibition of agglutination.

#

NI; non-inhibitory at the maximum tested concentration.