Fig. 3. The Mutual Exclusivity tab.

The example shows that genes that alter RB signaling in glioblastoma have a tendency toward mutual exclusivity. This tab provides summary statistics on mutual exclusivity and co-occurrence of genomic alterations in each pair of query genes. In this example, all three pairs have a tendency toward mutual exclusivity. Although the CDK4-RB1 pair has the strongest tendency toward mutual exclusivity (dark blue background), the relationship is not statistically significant (P = 0.11). The mutual exclusivity is significant for the other two gene pairs (P < 0.05, red outline). The P values are determined by a Fisher's exact test with the null hypothesis that the frequency of occurrence of a pair of alterations in two genes is proportional to their uncorrelated occurrence in each gene.