Table 1.

Concentration of ¹⁴C-bromfenac in ocular tissues over 12 hours following topical administration of ¹⁴C-bromfenac 0.07%, pH 7.8 or ¹⁴C-bromfenac 0.09%, pH 8.3

Sample, mean (SD)	Mean (± SD) bromfenac equivalents in μg eq/g
	1 hour		2 hours		4 hours		8 hours		12 hours
	0.07%, pH 7.8	0.09%, pH 8.3	0.07%, pH 7.8	0.09%, pH 8.3	0.07%, pH 7.8	0.09%, pH 8.3	0.07%, pH 7.8	0.09%, pH 8.3	0.07%, pH 7.8	0.09%, pH 8.3
Aqueous humor	0.048	0.051	0.090	0.137	0.038	0.052	0.018	0.018	0.011	0.010
	(0.024)	(0.017)	(0.024)	(0.063)	(0.011)	(0.021)	(0.004)	(0.015)	(0.003)	(0.005)
Vitreous humor	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.001
	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)	(0.000)
Iris/ciliary body	0.081	0.078	0.110	0.083	0.048	0.061	0.029	0.034	0.018	0.022
	(0.037)	(0.027)	(0.044)	(0.013)	(0.005)	(0.016)	(0.013)	(0.017)	(0.001)	(0.009)
Lens	0.001	0.002	0.003	0.002	0.002	0.002	0.002	0.002	0.002	0.003
	(0.000)	(0.001)	(0.001)	(0.001)	(0.000)	(0.000)	(0.001)	(0.002)	(0.000)	(0.003)
Retina	0.013	0.018	0.010	0.015	0.006	0.010	0.002	0.002	0.003	0.002
	(0.005)	(0.005)	(0.002)	(0.003)	(0.001)	(0.004)	(0.000)	(0.001)	(0.004)	(0.001)
Choroid	0.045	0.058	0.062	0.083	0.035	0.043	0.011	0.010	0.008	0.008
	(0.012)	(0.010)	(0.011)	(0.030)	(0.007)	(0.022)	(0.004)	(0.004)	(0.002)	(0.002)
Sclera	0.595	0.346	0.451	0.302	0.170	0.220	0.058	0.026	0.067	0.039
	(0.156)	(0.134)	(0.028)	(0.006)	(0.026)	(0.160)	(0.019)	(0.020)	(0.045)	(0.015)
Total	0.783	0.553	0.726	0.623	0.300	0.388	0.121	0.092	0.109	0.085
	(0.231)	(0.186)	(0.088)	(0.080)	(0.048)	(0.218)	(0.005)	(0.058)	(0.043)	(0.031)

Notes: N=15 for each treatment, three rabbits per time point. All differences between formulations were statistically insignificant at all time points with the exception of the 2-hour scleral drug level (P<0.001). All differences between formulations in total drug levels were statistically insignificant (P>0.20) using a Student’s t-test, without correction for multiple comparisons.

Abbreviation: SD, standard deviation.