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(A) 1,3-cycloaddition of Prato reaction with synthesized amine-modified glycine (B) 1,3-cycloaddition employing purchasable H-Lys(Boc)-OH, with handle emerging from the chiral carbon center.
Abbreviations: DMF, dimethylformamide; PFA, paraformaldehyde; TFA, trifluoroacetic acid; Boc, (tert-Butyloxycarbonyl); Lys, lysine.
