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Figure 2. Current understanding of flow-induced Rac1 polarization in endothelial cells. Mechanotransduction of shear stress results in PECAM-1-dependent Src activation. Src activates the GEF Vav2, which promotes Rac1 GTP-loading. Rac associates with a polarity complex consisting of VE-cadherin, Tiam1, p67phox, and Nox and the downstream edge of the cell and results in ROS production.
