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. 2014 Sep 8;30(5):496–508. doi: 10.1016/j.devcel.2014.08.016

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© 2014 The Authors

This work is licensed under a Creative Commons Attribution 3.0 Unported License.

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Neocentromere Generation in Various Experimental Systems

(A) Isolation of surviving cells after removal of the endogenous centromere on a chromosome by homologous recombination between two LoxP loci flanking the centromere. Surviving cells usually have segregation of the chromosome directed by a neocentromere.

(B) Ectopic CENP-A is assembled into a “CENP-A cloud” flanking the endogenous centromere in chicken cells. A CENP-A-rich region might be created by specific 3D packaging of the genome in Candida nuclei. The ectopic CENP-A functions as a site of preferential neocentromere formation in chicken or Candida cells when the endogenous centromere is disrupted. In contrast, neocentromeres are preferentially formed on telomeres in S. pombe.