Table 1.

Family-based association test analysis of ZNF804A with autism

				Families†		Frequency		p value‡
SNP	Physical position	Allele*	Location	All§	Lvrb§	All§	Lvrb§	All§	Lvrb§
rs13393273	185185922	A	Intron 1	591	532	0.619	0.618	0.24	0.08
		G				0.381	0.382
rs12613195	185197466	C	Intron 1	551	499	0.682	0.679	0.57	0.59
		G				0.318	0.321
rs12693385	185215474	T	Intron 1	604	548	0.520	0.518	0.60	0.40
		C				0.480	0.482
rs990844	185227330	T	Intron 1	323	287	0.867	0.869	0.24	0.10
		G				0.133	0.131
rs7597593	185241825	C	Intron 1	617	549	0.600	0.602	0.50	0.22
		T				0.400	0.398
rs1038197	185265516	A	Intron 1	480	429	0.760	0.764	0.11	0.08
		G				0.240	0.236
rs13026742	185313227	C	Intron 1	597	536	0.579	0.579	0.18	0.25
		T				0.421	0.421
rs1987025	185355840	T	Intron 1	479	425	0.750	0.746	0.12	0.09
		A				0.250	0.254
rs17509608	185440823	C	Intron 2	295	270	0.892	0.892	0.74	> 0.99
		T				0.108	0.108
rs7603001	185475061	G	Intron 2	596	539	0.510	0.506	0.018	0.008
		A				0.490	0.494
rs1344706	185486673	T	Intron 2	584	524	0.637	0.635	0.16	0.13
		G				0.363	0.365
rs7593816	185490557	C	Intron 2	412	375	0.809	0.806	0.59	0.45
		T				0.191	0.194
rs3731834	185511609	C	Exon 4 (L/V)	388	349	0.830	0.833	0.29	0.48
		G				0.170	0.167
rs10931157	185513698	A	3′	542	484	0.704	0.702	0.21	0.06
		G				0.296	0.298
rs12693402	185516324	C	3′	396	351	0.822	0.826	0.20	0.07
		T				0.178	0.174
rs4380187	185520185	A	3′	616	554	0.570	0.567	0.50	0.46
		C				0.430	0.433

L/V = leucine/valine; Lvrb = autistic, low verbal; SNP = single nucleotide polymorphism; ZNF804A = zinc finger protein 804A.

^*Major allele is listed first.

^†No. of informative families used.

^‡p < 0.05, additive model.

^§Whole set of 841 pedigrees; Lvrb: 761 pedigrees.