Table 2.
Baseline levels of cytokines and angiogenic factors.
| Characteristics | Median Value (min, max) (pg/mL) |
|---|---|
| Cytokine and Angiogenic Factors | |
|
| |
| Basic-FGF | 2.35 (-2.25, 4.97) |
| HGF | 11.28 (8.64, 14.35) |
| IL-6 | 13.40 (10.35, 15.17) |
| IL-8 | 7.72 (5.19, 10.01) |
| MCP-1 | 9.52 (4.22, 12.54) |
| IL-1a | 2.17 (-4.06, 3.61) |
| IL-1b | 3.95 (3.17, 4.39) |
| TNFα | 4.89 (2.28, 6.37) |
| VEGF | 10.66 (8.04, 12.75) |
| PDGF-bb | 4.06 (1.31, 6.51) |
| INF-a2 | 7.35 (6.46, 7.79) |
| INF-γ | 7.28 (3.81, 8.9) |
| IL-12p70 | 7.53 (5.71, 8.87) |
| IP-10 | 13.23 (9.59, 15.52) |
| MIG | 11.45 (10.09, 15.55) |
| IL-12P40 | 9.82 (7.48, 11.28) |
|
| |
| Markers of hypoxia | |
|
| |
| CA-9 | 11.01 (8.64, 13.36) |
| Osteopontin | 10.04 (6.92, 10.21) |
|
| |
| Hematopoietic growth factors | |
|
| |
| GM-CSF | 6.28 (0.73, 8.34) |
| G-CSF | 5.29 (4.07, 7.44) |
| M-CSF | 5.77 (3.45, 6.79) |
| SCF | 9.56 (8.46, 11.1) |
| Soluble VEGFR2 | 12.08 (11.13, 12.95) |
|
| |
| Other interleukins | |
|
| |
| IL-13 | 5.89 (4.27, 7.99) |
| IL-16 | 10.32 (9.06, 11.09) |
| IL-18 | 6.86 (5.48, 7.83) |
| IL-1 RA | 5.38 (0.58, 10.08) |
| IL-2 RA | 9.78 (9.19, 10.94) |
| IL-3 | 7.67 (5.72, 8.72) |
| IL-4 | 0.99 (-4.32, 4.19) |
| IL-5 | 2.47 (0.24, 6.09) |
| IL-7 | 3.50 (2.41, 5.47) |
| IL-9 | 5.12 (2.4, 8.57) |
| IL-10 | 4.98 (4.18, 8.61) |
| IL-15 | 6.12 (5.47, 6.33) |
| IL-17 | 4.09 (3.91, 6.06) |
|
| |
| Other cytokines and chemokines | |
|
| |
| IL-2 | 4.64 (4.57, 5.99) |
| MIP-1a | 5.08 (4.46, 5.86) |
| MIP-1b | 5.05 (1.53, 11.06) |
| Eotaxin | 6.77 (5.53, 8.31) |
| RANTES | 5.90 (3.22, 8.49) |
| CCL27/CTACK | 9.80 (8.73, 10.73) |
| CXCL1/GRO-Q | 7.33 (1.92, 11.48) |
| LIF | 5.51 (0.4, 7.17) |
| MCP-3L/CCL7 | 5.03 (-1.32, 6.45) |
| MIF | 9.92 (8.99, 12.67) |
| SDF-1a/CXCL-12 | 8.56 (7.66, 9.15) |
| SCGF-b | 17.41 (16.44, 18.05) |
|
| |
| Growth factors and receptors | |
|
| |
| EGFR | 11.64 (10.52, 12.17) |
| Amphiregulin | 9.74 (7.37, 13.39) |
| Epiregulin | 0.60 (-2.74, 5.13) |
| EGF | 2.43 (-1.64, 4.74) |
| Betacellulin | 2.05 (-1.29, 4.81) |
| b-NGF | 2.48 (-2.74, 3.71) |
| IGF-I | 7.01 (5.86, 8.18) |
| IGFBP-3 | 10.28 (9.14, 10.85) |
| TRAIL | 5.45 (3.6, 7.44) |
|
| |
| Coagulation proteins | |
|
| |
| Gas-6 | 14.03 (12.96, 14.36) |
|
| |
| Adhesion molecules | |
|
| |
| Tenascin | 12.17 (9.96, 14.33) |
| VCAM-1 | 16.71 (16.35, 17.61) |
| ICAM-1 | 17.37 (15.95, 19.06) |
| NGAL | 7.19 (5.69, 7.71) |
| PIGF | 9.62 (8.88, 11.35) |
Definition of abbreviations: CA-9= carbonic anhydrase 9; EGF = epidermal growth factor; EGFR = epidermal growth factor receptor; FGF = basic fibroblast growth factor; Gas-6 = growth arrest-specific 6; G-CSF = granulocyte colony-stimulating factor; HGF = hepatocyte growth factor; ICAM-1 = intercellular adhesion molecule 1; IL = interleukin; MMP = matrix metalloproteinase; IL-1RA = interleukin-1 receptor antagonist; INF = interferon; MIG = monokine induced by interferon gamma; IP-10 = interferon gamma– induced protein 10; LIF= leukemia inhibitory factor; MCP-3L/CCL7 = monocyte-specific chemokine-3; M-CSF = macrophage colony-stimulating factor; MCP-1 = macrophage chemoattractan protein-1; MIG = monokine induced by gamma interferon; MIF = macrophage migration inhibitory factor; MIP = macrophage inflammatory protein; NGAL = neutrophil gelatinase-associated lipocalin; PDGF= platelet derived growth factor; PIGF = phosphatidylinositol-glycan biosynthesis class F protein; SCGF-b=stem cell growth factor-beta; SCF = stem cell factor; SDF-1 = stromal cell-derived factor-1; TNF = tumor necrosis factor; TRAIL = TNF-related apoptosis-inducing ligand; VEGF = vascular endothelial growth factor; VEGFR2 = vascular endothelial growth factor.