Table 4. Cumulative toxicity.
| Toxicity | No. (%) of Patients | |||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Anemia | 1 (5) | |||
| Thrombocytopenia | 2 (10) | |||
| Prolonged PTT | 1 (5) | |||
| Fatigue | 2 (10) | 1 (5) | 4 (20) | |
| Weight loss | 4 (20) | 1 (5) | ||
| Anorexia | 2 (10) | |||
| Nausea | 3 (15) | |||
| Vomiting | 1 (5) | |||
| Diarrhea | 8 (40) | 3 (15) | 1 (5) | |
| Constipation | 1 (5) | |||
| Xerostomia | 2 (10) | |||
| Abdominal | 1 (5) | |||
| Distension/bloating | ||||
| Muscle weakness | 1 (5) | |||
| Prolonged QTc | 1 (5) | 2 (10) | 2 (10) | |
| Cardiac arrhythmia | 1 (5) | 1 (5) | 1 (5) | |
| Palpitations Hypertension | 1 (5) | 1 (5) | ||
| Premature ventricular contractions | 1 (5) | |||
| Acne | 2 (10) | |||
| Dry skin | 1 (5) | |||
| Erythema multiforme | 4 (20) | |||
| Rash/desquamation | 3 (15) | 1 (5) | ||
| Sweating | 1 (5) | |||
| Pneumothorax | 1 (5) | |||
| Dyspnea | 1 (5) | 1 (5) | ||
| Hypoxia | 1 (5) | |||
| Infection with normal ANC | 1 (5) | |||
| Hypomagnesemia | 4 (20) | 1 (5) | ||
| Hypokalemia | 3 (15) | 1 (5) | ||
| Hyponatremia | 1 (5) | |||
| Hypophosphatemia | 3 (15) | |||
| Hyperkalemia | 1 (5) | |||
| Dizziness | 1 (5) | |||
No.= number; ANC=absolute neutrophil count; PTT=partial thromboplastin time.