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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Menopause. 2014 Oct;21(10):1160–1164. doi: 10.1097/GME.0000000000000220

Figure 3.

Figure 3

The success of estrogen replacement therapy is dependent on the menopausal status of a woman. (A) Estrogen withdrawal in postmenopausal women causes ER positive dependent cells to die but some cells continue to grow independent of estrogen. (B) Treatment of women immediately after menopause with CEE results in sustained growth of nascent ER positive tumors, whereas treatment 5 years after menopause causes apoptotic cell death (Obiorah I and Jordan VC 2013 Menopause 20:372–382 reproduced with permission)