Table 1.

Kaplan-Meier analysis of overall survival after local recurrence

Factor	Group	Number of patients	Median survival (months)	95% CI for survival		p value
Age	< 18 years	19	32	4	60	0.56
	≥ 18 years	26	17	7	27
Sex	Male	30	52	17	87	0.04
	Female	15	11	9	14
Site	Extremity	36	17	14	20	0.37
	Pelvis	9	59	0	149
Tissue	Bone	10	52	8	95	0.99
	Soft tissue	35	17	14	20
Necrosis of primary tumor	< 90%	28	15	9	21	0.03
	≥ 90%	17	60	22	99
Necrosis of recurrent tumor	< 50%	14	52	0	108	0.71
	≥ 50%	11	32	0	79
Chemotherapy	Yes	37	18	0	37	0.53
	No	8	17	0	38.5
Ifosfamide	Yes	23	17	8	26	0.16
	No	14	60	0	151
Surgery	Limb-sparing	13	32	6	57	0.28
	Amputation	18	17	13	21
Time to recur	< 12 months	15	15	9	21	0.05
	≥ 12 months	30	33	0	78
Time to recur	< 24 months	28	15	10	21	0.03
	≥ 24 months	17	52	4	100
Time period	1985–95	21	16	13	19	0.97
	1996–2007	24	32	0	68
Systemic recurrence	Local recurrence without systemic recurrence	19	60	4	116	0.01
	Local recurrence with systemic recurrence	17	11	6	17
	Local recurrence after systemic recurrence	9	18	0	39
Recurrence size	< 5 cm	9	84	44	124	< 0.0001
	≥ 5 cm	36	15	9	22