Table 1.
Relative mRNA levels for the Slc4a and Slc26a anion transporters in mouse heart
| SLC4A family | SLC26A family | ||||
|
Gene symbol |
Transporter name and major function(s);
alternate names |
Average ± SE |
Gene symbol |
Transporter name and major function(s);
alternate names |
Average ± SE |
| Slc4a1 | AE1 Cl-/HCO3- exchanger; Band 3 | 0.2 ± 0.05 | Slc26a1 | SAT1 sulfate/anion exchanger; Slc26a1 | 0.34 ± 0.07 |
| Slc4a2 | AE2 Cl-/HCO3- exchanger | 12.57 ± 0.28 | Slc26a2 | DTDST sulfate/anion exchanger; Slc26a2 | 2.98 ± 0.17 |
| Slc4a3 | AE3 Cl-/HCO3- exchanger | 85.7 ± 0.64 | Slc26a3 | DRA Cl-/HCO3-, exchanger; Slc26a3 | 0.64 ± 0.05 |
| Slc4a4 | NBCe1 Na+/HCO3- cotransporter; NBC1 | 9.45 ± 0.25 | Slc26a4 | Pendrin Cl-/HCO3- exchanger; Slc26a4 | 0.02 ± 0.01 |
| Slc4a5 | NBCe2 Na+/HCO3- cotransporter; NBC4 | 0.003 ± 0.002 | Slc26a6 | PAT1 Cl-/HCO3-, Cl-/formate exchanger; Slc26a6 | 4.56 ± 0.26 |
| Slc4a7 | NBCn1 Na+/HCO3- cotransporter; NBC2; NBC3 | 4.24 ± 0.05 | Slc26a7 | Slc26a7 Cl-/HCO3- exchanger, Cl- channel; TAT1 | 0.15 ± 0.04 |
| Slc4a8 | NDCBE Na+-driven Cl-/HCO3- exchanger; Slc4a8 | 0.73 ± 0.04 | Slc26a9 | Slc26a9 Cl-/HCO3- exchanger, Cl- channel | 0.01 ± 0.01 |
| Slc4a9 | AE4 Cl-/HCO3- exchanger | 0.02 ± 0.01 | Slc26a10 | Slc26a10, transporter function unknown | 31.66 ± 2.55 |
| Slc4a10 | NBCn2 Na+/HCO3- cotransporter | 0.02 ± 0.003 | Slc26a11 | Slc26a11 anion exchanger, Cl- channel; KBAT | 1.15 ± 0.14 |
Relative mRNA expression levels were determined using RNA from 4-month-old male FVB/N mouse hearts (n = 4) as described previously[51]. Values are RPKM (reads per kilobase per million mapped reads) ± SE and are a measure of the relative abundance of specific gene transcripts[53]. For some Slc26a transporters, ion transport specificities are more complex than indicated; see Alper and Sharma[9].