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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cancer Res. 2013 Dec 10;74(1):3–7. doi: 10.1158/0008-5472.CAN-13-1742

Figure 1.

Figure 1

Summary of the vascularization continuum. The vascularization continuum recognizes the multiple mechanisms by which tumor cells will vascularize to survive and grow (simplified here to only consider dominant mechanisms of vessel cooption and remodeling). Aggressive tumor growth is characterized by angiogenesis, often with cooption at the growth fronts. When VEGF-dependent angiogenesis is blocked with agents such as bevacizumab, the vascularization continuum shunts toward vessel cooption and related β1 integrin-mediated tumor cell functions. Blue denotes blood vessels, and red denotes cancer cells.