Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 26;6(8):64. doi: 10.1186/s13073-014-0064-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Fang and Gough; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Evolutionary age of genes in the survival network. This is a heatmap of the mutation frequency of genes (in rows) versus tumour types (in columns). The tumour types are ordered based on a neighbour-joining tree (built from the mutation frequency matrix). The evolutionary history of genes is based on species tree of life (sTOL [29]). The left panel indicates the ancestor in which genes first appeared. Ancestor enrichment analysis shows that these survival genes contain a significantly higher number of genes first created at Metazoa, Deuterostomia and Chordata (framed in blue; FDR <0.05). Indicated beside the gene symbols are their Cox P values: *<0.05; **<0.01 and ***<0.005. Abbreviations for tumour types are the same as described in Figure 5.