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. 2014 Sep 2;12:237. doi: 10.1186/s12967-014-0237-7

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© Lai et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TFPI-2 reduced OSCC metastasis in vivo. (A) IG- or TIG-transduced OC2 cells were intravenously injected into the tail veins of athymic BALB/c nude mice (n = 5 in the IG group; n = 7 in the TIG group). Forty days after tumor cell inoculation, the number of pulmonary metastatic nodules derived from circulating cells in each mouse was counted. The Mann–Whitney U test was used to compare the numbers of tumor nodules between groups. *, P = 0.023. (B) Representative photograph of lung tissues excised from the mice.