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. 2014 Sep 11;109(6):436. doi: 10.1007/s00395-014-0436-7

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© The Author(s) 2014

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 6 — Effects of class I–III (Redfern) drugs on rat EHT relaxation time (T2). a Shows the effect of antiarrhythmics (class I), b of drugs which were withdrawn from the market (class II) and c of drugs with measureable incidence of TdP. Each symbol reflects one analyzed EHT. Different concentrations are indicated by different symbols (baseline , 1×, 10×, 100× FTPC). Statistically significant changes in T2 are indicated by an asterisk behind the drug name. Effects other than T2 prolongations are indicated by hashtag (e.g., thioridazine: irregular beating). Data are expressed as percent of baseline (50 nM epinephrine). *p < 0.05 paired Student’s t test vs. baseline and at least 15 % difference between means

Inline graphic — Effects of class I–III (Redfern) drugs on rat EHT relaxation time (T2). a Shows the effect of antiarrhythmics (class I), b of drugs which were withdrawn from the market (class II) and c of drugs with measureable incidence of TdP. Each symbol reflects one analyzed EHT. Different concentrations are indicated by different symbols (baseline , 1×, 10×, 100× FTPC). Statistically significant changes in T2 are indicated by an asterisk behind the drug name. Effects other than T2 prolongations are indicated by hashtag (e.g., thioridazine: irregular beating). Data are expressed as percent of baseline (50 nM epinephrine). *p < 0.05 paired Student’s t test vs. baseline and at least 15 % difference between means