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. 2014 Sep 11;109(6):436. doi: 10.1007/s00395-014-0436-7

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© The Author(s) 2014

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 7 — Effects of class IV–V (Redfern) drugs on rat EHT relaxation time (T2). a Shows the effect of drugs with isolated reports of TdP (class IV) and b with no reports of TdP in humans (class V). Each symbol reflects one analyzed EHT. Different concentrations are indicated by different symbols (baseline , 1×, 10×, 100× FTPC). Statistical significant changes in T2 are indicated by an asterisk behind the drug name. Effects other than T2 prolongations are indicated by hashtag (e.g., verapamil: negative inotropic effect). Data are expressed as percent of baseline (50 nM epinephrine). *p < 0.05 paired Student’s t test vs. baseline and at least 15 % difference between means

Inline graphic — Effects of class IV–V (Redfern) drugs on rat EHT relaxation time (T2). a Shows the effect of drugs with isolated reports of TdP (class IV) and b with no reports of TdP in humans (class V). Each symbol reflects one analyzed EHT. Different concentrations are indicated by different symbols (baseline , 1×, 10×, 100× FTPC). Statistical significant changes in T2 are indicated by an asterisk behind the drug name. Effects other than T2 prolongations are indicated by hashtag (e.g., verapamil: negative inotropic effect). Data are expressed as percent of baseline (50 nM epinephrine). *p < 0.05 paired Student’s t test vs. baseline and at least 15 % difference between means