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. 2013 Nov 27;25(3):219–228. doi: 10.1007/s12022-013-9277-4

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© The Author(s) 2013

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 1 — IHC for VGF. a A NE breast cancer (case 2) shows IHC expression of VGF of variable intensity in the vast majority of cancer cells. b VGF positivity in an invasive carcinoma, no special type (IC-NST) breast cancer (case 5) displaying solid histological patterns. c The in situ (right) and invasive glandular component in case 10 have different positivity for VGF, which is more intense in the former. d Immunohistochemical staining for chromogranin A shows scattered positive cells. The tumour (case 28) showed gene expression positivity for the same NE marker (×100, nuclei counterstained with Haemalum)