Table 1.
Histopathological and molecular features of the study cohort
| Case no. | Histological type | G | Gene expression | IHC | ||||
|---|---|---|---|---|---|---|---|---|
| CHGA | SYP | VGF | ER | HER2 | Ki67 | |||
| 1 | NE | 2 | +++ | +++ | +++ | 100 | 0 | 16 |
| 2 | Mucinous NE | 1 | ++ | +++ | + | 100 | 1 | 2 |
| 3 | NE | 3 | − | +++ | ++ | 0 | 0 | 35 |
| 4 | NE | 2 | +++ | ++ | +++ | 100 | 0 | 23 |
| 5 | IC + mucinous | 3 | ++ | − | ++ | 70 | 3 | 35 |
| 6 | IC-NST | 3 | − | − | ++ | 0 | 0 | 43 |
| 7 | IC-NST | 2 | − | − | ++ | 4 | 0 | 60 |
| 8 | IC-NST | 3 | − | + | ++ | 0 | 0 | 70 |
| 9 | IC-NST | 3 | − | − | ++ | 0 | 0 | 70 |
| 10 | IC-NST | 2 | − | − | ++ | 5 | 1 | 17 |
| 11 | IC-NST | 3 | − | − | ++ | 0 | 3 | 43 |
| 12 | IC-NST | 3 | − | − | ++ | 95 | 3 | 16 |
| 13 | IC-NST | 2 | − | − | + | 0 | 0 | 44 |
| 14 | Medullary | 3 | − | − | + | 0 | 0 | 25 |
| 15 | IC-NST | 3 | − | − | + | 1 | 0 | 60 |
| 16 | Intracystic papillary | 1 | − | − | − | 100 | 0 | 20 |
| 17 | IC-NST | 2 | − | − | − | 95 | 1 | 28 |
| 18 | IC-NST | 2 | − | − | − | 95 | 0 | 21 |
| 19 | IC-NST | 1 | − | − | − | 90 | 1 | 28 |
| 20 | IC-NST | 2 | − | + | − | 100 | 1 | 14 |
| 21 | Intracystic papillary | 1 | − | − | − | 100 | 1 | 18 |
| 22 | IC-NST | 2 | − | − | − | 100 | 0 | 9 |
| 23 | IC-NST | 2 | − | − | − | 95 | 1 | 30 |
| 24 | Tubular | 1 | − | − | − | 95 | 1 | 19 |
| 25 | ILC | 2 | − | − | − | 88 | 0 | 11 |
| 26 | IC-NST | 2 | − | + | − | 95 | 1 | 6 |
| 27 | IC-NST | 3 | − | − | − | 65 | 3 | 34 |
| 28 | IC-NST | 3 | +++ | − | − | 95 | 3 | 25 |
CHGA chromogranin A, ER estrogen receptor, G histological grade, IC-NST invasive carcinoma not special type, IHC immunohistochemistry, Lum luminal, NE neuroendocrine, SYP synaptophsyn, +++ overexpression