Table 2.
Incidence of postoperative cognitive dysfunction (POCD) for melatonin versus placebo.
| Variable | Placebo 14 (12.75–14) days after surgery |
Melatonin 13 (11–15) days after surgery |
P | Placebo 84 (80–86) days after surgery |
Melatonin 85 (83–91) days after surgery |
P |
|---|---|---|---|---|---|---|
| POCD (yes/no) | 0/20 | 0/26 | 1.00 | 1/15 | 0/26 | 0.38 |
| 0% [0.0%; 16.8%] | 0% [0%; 13.2%] | 6.3% [0.0%; 30.2%] | 0% [0.0%; 13.2%] |
Calculations based on normative data from 133 females aged 40–60 years [30].
P value: Fisher's test.
Neuropsychological testing in median (IQR) days after surgery.
Values are number of patients, percentages, and 95% confidence intervals.