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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Aug 4;(8):CD007667. doi: 10.1002/14651858.CD007667.pub2
Methods Design: placebo-controlled parallel trial.
Participants Participants: outpatients with repeated suicidal attempts but without major depression
Sex: 37 male; 54 female (data not extractable for any AsPD subgroup; see note 1)
Age: mean 34.1 (SD 11.6) and 37.1 (SD 13.0) years (data not extractable for any AsPD subgroup; see note 1)
Unit of allocation: individual participant.
Number randomised: 91 (paroxetine, n = 46; placebo, n = 44) (see note 1). Number completing: at 8 weeks (paroxetine, n = 28; placebo, n = 30); at 52 weeks (paroxetine, n = 11; placebo, n = 8) (see note 1)
Setting: outpatient; 2 sites; Netherlands (Rotterdam, Leiden).
Inclusion criteria: at least one previous suicide attempt; aged 18 yrs or older
Exclusion criteria: major affective disorder; psychotic disorder; currently taking antidepressant or antipsychotic medication; organic mental disorder; dependency on alcohol or substances; using prohibited medication; serious physical disease; unable to co-operate
Ethnicity: not reported.
Interventions Two conditions: paroxetine/ placebo.
  • paroxetine (oral, 40 mg, once daily) (number randomised unclear).

  • placebo (oral, once daily) (number randomised unclear).


In addition to medication, supportive psychotherapy offered weekly to fortnightly to all participants
Duration of intervention: up to 52 weeks.
Duration of trial: up to 52 weeks.
Length of follow up: participants were not followed up beyond the end of the intervention period
Dose adjustment: initial placebo washout period of 2 weeks; then 20 mg/day paroxetine for one week followed by a fixed dose of 40 mg/day for up to 52 weeks (or matching placebo)
Outcomes Primary outcomes
none.
Secondary outcomes
Leaving the study early:
Anger: STAXI scores.
Other outcomes
subsequent suicide attempts; depression (Beck Depression Inventory; self report); hopelessness (Beck Hopelessness Scale, self-report)
Notes 1. study may have recruited a subgroup with AsPD as 74 participants had DSM-III-R Cluster B personality disorder, although this is unclear. No data extractable on any AsPD subgroup. Awaiting clarification from investigators

RCT: randomised controlled trial