Methods | Randomisation by opaque sealed envelopes. | |
Participants | 2000 pregnant women attending the ultrasound department for routine third trimester scans, including multiple pregnancies | |
Interventions | All women were offered routine early pregnancy ultrasound and 2 routine scans in the third trimester. Placental grading was performed at the routine third trimester scan. The results of placental grading in the study group were revealed, and the control group concealed. Clinical management in both groups was left entirely to the clinician responsible for care | |
Outcomes | Obstetric interventions (antepartum and intrapartum) and perinatal outcome indices | |
Notes | This study addresses the value of placental grading at routine third trimester ultrasound | |
Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Unclear | Described as “randomly allocated to 1 of 2 groups”. |
Allocation concealment? | Yes | Described as “a correspondingly numbered, sealed, opaque envelope” |
Blinding? Women |
No | Not feasible. |
Blinding? Clinical staff |
No | Not feasible. |
Blinding? Outcome assessors |
No | Not feasible. |
Incomplete outcome data addressed? All outcomes |
Yes | No losses to follow up. |
Free of selective reporting? | Yes | Selective outcome reporting not detected. |
Free of other bias? | Yes | No other bias apparent. |