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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cochrane Database Syst Rev. 2008 Oct 8;(4):CD001451. doi: 10.1002/14651858.CD001451.pub3
Methods Randomisation by opaque sealed envelopes.
Participants 2000 pregnant women attending the ultrasound department for routine third trimester scans, including multiple pregnancies
Interventions All women were offered routine early pregnancy ultrasound and 2 routine scans in the third trimester. Placental grading was performed at the routine third trimester scan. The results of placental grading in the study group were revealed, and the control group concealed. Clinical management in both groups was left entirely to the clinician responsible for care
Outcomes Obstetric interventions (antepartum and intrapartum) and perinatal outcome indices
Notes This study addresses the value of placental grading at routine third trimester ultrasound
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Described as “randomly allocated to 1 of 2 groups”.
Allocation concealment? Yes Described as “a correspondingly numbered, sealed, opaque envelope”
Blinding?
Women
No Not feasible.
Blinding?
Clinical staff
No Not feasible.
Blinding?
Outcome assessors
No Not feasible.
Incomplete outcome data addressed?
All outcomes
Yes No losses to follow up.
Free of selective reporting? Yes Selective outcome reporting not detected.
Free of other bias? Yes No other bias apparent.