Table 3. False-Positive Report Probability Values for associations between ESCC risk and genotypes of ERCC2 polymorphisms.
| Prior probability | ||||||||
|---|---|---|---|---|---|---|---|---|
| Genotypes | Positive OR (95% CI) a | P value b | Statistical Power c | 0.2500 | 0.1000 | 0.0100 | 0.0010 | 0.0001 |
| rs238406 | ||||||||
| TT vs. GG | 1.24 (0.98–1.57) | 0.075 | 0.988 | 0.185 | 0.406 | 0.883 | 0.987 | 0.999 |
| TG/TT vs. GG | 1.24 (1.04–1.49) | 0.017 | 0.975 | 0.050 | 0.136 | 0.633 | 0.946 | 0.994 |
| Pack-years > 16 | 1.49 (1.12–1.98) | 0.006 | 0.523 | 0.033 | 0.094 | 0.532 | 0.920 | 0.991 |
| Combined risk genotypes | ||||||||
| No. at-risk genotypes d | ||||||||
| 1 vs. 0 | 1.25 (1.03–1.52) | 0.026 | 0.984 | 0.073 | 0.192 | 0.723 | 0.964 | 0.996 |
| 2 vs. 0 | 1.62 (1.16–2.26) | 0.005 | 0.452 | 0.032 | 0.091 | 0.523 | 0.917 | 0.991 |
| ≥1 vs. 0 | 1.28 (1.06–1.56) | 0.011 | 0.930 | 0.034 | 0.096 | 0.539 | 0.922 | 0.992 |
aThe crude OR reported in Tables 2 and 3.
bThe omnibus chi-square test of the genotype frequency distributions reported in Tables 2 and 3.
cStatistical power was calculated using the number of observations in the study and the OR and P values in Tables 2 and 3.
dCombined risk genotypes were to referred to ERCC2 rs238406 TG/TT + rs13181 TG/GG.