A significant reduction in protein levels of NR2B was observed in (a) dorsomedial prefrontal cortex (dmPFC), (b) dorsal hippocampus (HPC), (c) dorsolateral striatum (DLS), and (d) nucleus accumbens (NAc) in NR2B deficient (KO) mice in comparison with wildtype (WT), CAM, and CRE mice (n = 4-7 males/genotype). NR1 expression levels in NR2B deficient mice were also significantly reduced in each of these regions. No significant changes in NR2A subunit expression levels were observed in any of the genotypes. * = differs from WT, CRE, CAM