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(A) Synthesis of bromopropyphenazone (BMP) and hydroxypropyphenazone (HPP). (B) Synthesis of ibuprofen–propyphenazone (IB–MP), diclofenac–propyphenazone (DIC–MP), ketoprofen–propyphenazone (KET–MP), betahistine–propyphenazone (BET–MP), and 4-aminoantipyrine–propyphenazone (ANT–MP) derivatives. (C) Chemical structures of the tested compounds.
