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. 2014 Jun 23;5(9):983–988. doi: 10.1021/ml500156v

Figure 2.

Figure 2

Effects of IB–MP (A), DIC–MP (B), and KET–MP (C) on the activity of ovine COXI and human COXII in the absence/presence of porcine liver esterase (PLE). Their activities were compared to the inhibitory effect of authentic samples of ibuprofen (IB) (A), diclofenac (DIC) (B), and ketoprofen (KET) (C). Absorption spectrum of each prodrug IB–MP (D), DIC–MP (E), and KET–MP (F) in the presence of porcine liver esterase (PLE) was monitored every 4 min for 100 min. The dashed line represents an initial absorbance spectrum before the addition of PLE. In each spectrum, one labeled line represents a spectrum of propyphenazone (PP), and the other labeled line depicts the absorption of an authentic sample of IB (D), DIC (E), and KET (F). The arrows indicate the direction of the spectral change over time.