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. 2014 Jun 23;5(9):983–988. doi: 10.1021/ml500156v

Figure 4.

Figure 4

Characterization of ANT–MP as a specific COXII inhibitor. (A) Differential effect of ANT–MP and ANT on COXI and COXII activity in the absence and presence of porcine liver esterase (PLE). Unlike the nonselective ANT, ANT–MP showed 100% selectivity toward COX-II enzyme. (B) Acute inflammation mitigation by ANT–MP, ANT and PP in carrageenan model mice. (C) The 3-dimensional structure of ANT–MP covered by lipohilic potential water accessible surface. The brown portion of the molecule represents the most lipophilic potential, while the blue portion is the least lipophilic (left). Surflex docking of ANT–MP (golden brown) into COXII active site (right).