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| |
+ porcine liver esterase |
||||
|---|---|---|---|---|---|
| compd | CoxI | CoxII | CoxI | CoxII | SIb |
| ANT–MP | no inhibition | 1.0 ± 0.04 (100%) | no inhibition | 1.0 ± 0.09 (100%) | Cox II selective |
| ANT | 26 ± 1.8 (100%) | 42 ± 1.1 (100%) | 0.6 | ||
| Celecoxib | 3027 | 0.0527 | 600 | ||
Values represent IC50 (μM) and % inhibition at saturation.
In vitro COXII selectivity index (CoxI IC50/CoxII IC50) calculated in the absence of PLE.
