Table 3. Analgesic Activity of the Mutual Prodrugsa.
no. of writhings per 20 min ± SE | % protection | |
---|---|---|
control | 62 ± 0.6 | 0 |
PP | 34 ± 0.9 | 45 |
IB | 25 ± 0.6 | 60 |
IB–MP | 3 ± 0.4 | 95 |
DIC | 23 ± 5 | 63 |
DIC–MP | 8 ± 2 | 87 |
KET | 21 ± 4 | 66 |
KET–MP | 17 ± 5 | 73 |
BET–MP | 34 ± 0.9 | 45 |
No. of writhings values were obtained by averaging three independent trials; data represent the mean ± SE.