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. 2014 Sep 10;34(37):12379–12393. doi: 10.1523/JNEUROSCI.1020-13.2014

Figure 1.

Figure 1.

PN-FLX treatment from either P2 to P21 or P2 to P11 enhances anxiety and depression-like behaviors in adult mice. A–C, In the novel OF test, FLX treatment from P2 to P21 or P2 to P11 results in significantly reduced time ambulating (A) and rearing (B); FLX treatment from P2 to P11 also results in significantly reduced time in the center region of the chamber (C). D–F, In the NSF test, FLX treatment from P2 to P21 or P2 to P11 significantly increases the latency to feed (D), while the percentage weight loss after 24 h food deprivation (E) and home-cage food consumption (F) are not affected by treatment. G–I, In the SESC test, FLX treatment from P2 to P21 or P2 to P11 results in significantly increased latency to escape (G) and suppressed activity between shocks (H), but does not affect activity during the pretest habituation phase (I). N values are indicated in the figure. *p < 0.05; **p < 0.01; ***p < 0.001.