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. 2014 Sep 10;34(37):12379–12393. doi: 10.1523/JNEUROSCI.1020-13.2014

Figure 4.

Figure 4.

PN-FLX treatment results in concurrent and opposite changes in IL and PL neuronal excitability. Input–output curves displaying frequency (in Hz) of spikes (action potentials) generated in response to increasing current injections (increased by 50 pA per step), from resting membrane potential. A, IL pyramidal neurons from PN-FLX mice display a significantly lower frequency of spikes in response current steps relative to PN-VEH controls. B, Conversely, prelimbic neurons from PN-FLX mice display significantly increased frequency of spikes in response to current injections. N = 3–6 mice/treatment; N values for cells per condition are indicated in the figure. **p < 0.01; ***p < 0.001.