Figure 8.

PL lesions in control mice do not affect anxiety-like behavior. Mice received bilateral injections in the PL using ibotenic acid (PL lesion) or saline solution (SHAM). A, B, Lesion extent was assessed histologically after behavioral experiments were concluded, with light gray demarcating the additive area lesioned, and dark gray demarcating the largest common area lesioned. C–E, In the OF test, PL lesions do not alter ambulatory time (C), time spent rearing (D), or time spent in the center region (E) relative to SHAM lesioned controls. F–H, In the NSF test, PL lesions do not affect the time to feed (F), percentage of weight loss after 24 h of food deprivation (G), or home-cage food consumption (H). I, K, PL lesions do not impact the latency to escape (I) or baseline pretrial activity (K) in the SESC test. J, PL lesions significantly increased the intratrial activity. N values are indicated in the figure. *p < 0.05.