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. 2014 Sep 10;34(37):12504–12514. doi: 10.1523/JNEUROSCI.0680-14.2014

Figure 2.

Figure 2.

Footshock-induced reinstatement of cocaine seeking is blocked by intra-vBNST injection of the β-2 AR antagonist, ICI-118,551, but not the β-1 AR antagonist, betaxolol. Data represent the effects of bilateral intra-vBNST injections of betaxolol (1 nmol/307 ng per side; A; n = 7) or ICI-118,551 (1 nmol/277 ng per side; B; n = 7) or vehicle on reinstatement (responses/2 h session ± SE) by electric footshock. Significant reinstatement was observed following intra-vBNST pretreatment with vehicle or betaxolol (*p < 0.05 vs Ext), but not ICI-118,551. Likewise, responding following ICI-118,551, but not betaxolol, was significantly reduced compared with vehicle pretreatment (#p < 0.05 vs vehicle). By contrast, intra-vBNST ICI-118,551 failed to altered food-reinforced lever pressing (C; n = 6).