Reinstatement of extinguished cocaine seeking by bilateral injection of the β-2 AR selective agonist, clenbuterol, but not the β-1 AR selective agonist, dobutamine, into the vBNST. Data represent responding on the cocaine lever (responses/2 h session ± SE; active) or a previously inactive lever. Intra-vBNST clenbuterol (36 pmol/10 ng per side; n = 10), but not dobutamine (1 nmol/301 ng per side; n = 7) reinstated extinguished cocaine seeking (*p < 0.05 vs vehicle). Neither dobutamine nor clenbuterol increased “inactive” lever responding.