Summary table E: Participants experiencing at least one adverse event (AE).

				At least one AE
		Number of		Number on		Percent with outcome
Drug	Dose (mg)	Studies	Patients	Active	Placebo	Active	Placebo	Relative risk (95% CI)	NNH (95% CI)
Aspirin	600/650	64	4965	19/76	20/88	13	11	1.2 (1.0 to 1.4)	44 (23 to 345)
Celecoxib	200	4	705	64/406	44/263	16	17	0.90 (0.63 to 1.28)
Celecoxib	400	4	620	107/315	87/206	34	42	1.05 (0.85 to 1.3)
Codeine	60	33	2411	81/399	63/399	20	16	1.3 (0.9 to 1.7)
Codeine + paracetamol	60 + 600/650	17	1413	266/779	83/479	34	17	1.6 (1.3 to 1.9)	6.0 (4.6 to 8.3)
Dexketoprofen	10/12.5	5	452	12/132	18/126	9	14	0.6 (0.3 to 1.3)
Dexketoprofen	20/25	6	523	43/220	26/193	20	13	1.3 (0.8 to 2.1)
Diclofenac	25	4	502	20/248	18/254	8	7	1.2 (0.6 to 2.1)
Diclofenac	50	11	1325	41/643	34/473	6	7	1.0(0.7 to 1.5)
Diclofenac	100	7	787	18/419	64/373	18	17	1.0 (0.8 to 1.4)
Diflunisal	250	3	195	4/98	7/97	4	7	0.6 (0.2 to 1.8)
Diflunisal	500	6	391	38/235	33/227	18	15	1.3 (0.8 to 1.9)
Diflunisal	1000	5	357	61/208	34/209	29	16	1.8 (1.2 to 2.6)	7.7 (4.8 to 20)
Dihydrocodeine	30	3	194	13/67	4/69	19	6	3.4 (1.2 to 9.8)	7.4 (4.1 to 38)
Etodolac	50	4	360	10/132	12/188	8	6	1.4 (0.6 to 3.2)
Etodolac	100	5	498	26/230	16/229	11	7	1.6 (0.9 to 2.8)
Etodolac	200	7	670	67/314	54/319	22	17	1.2 (0.9 to 1.7)
Etodolac	400	3	222	43/154	37/109	28	34	0.8 (0.6 to 1.2)
Etoricoxib	120/180/240	5	725	190/551	67/174	34	38	0.9(0.7 to 1.1)
Fenoprofen	200	4	287	9/146	9/141	6	6	0.94 (0.4 to 2.1)
Flurbiprofen	25	3	208	15/109	17/112	14	16	0.95 (0.5 to 1.7)
Flurbiprofen	50	10	692	37/284	50/290	13	17	0.75 (0.5 to 1.1)
Flurbiprofen	100	7	416	20/200	24/203	10	12	0.86 (0.5 to 1.5)
Gabapentin	250	3	327	49/177	49/152	28	32	0.9(0.7 to 1.3)
Ibuprofen	50	3	316	11/114	8/111	10	7	1.3 (0.6 to 3.0)
Ibuprofen	100	4	396	22/152	20/158	14	13	1.2(0.7 to 2.1)
Ibuprofen	200	20	2690	208/1102	137/706	19	19	0.9(0.7 to 1.02)
Ibuprofen	400	61	6475	476/2870	326/1997	17	16	0.9 (0.8 to 1.04)
Ketoprofen	12.5	3	274	8/138	6/136	6	4	1.3 (0.5 to 3.6)
Ketoprofen	25	8	535	27/259	22/231	10	10	1.2(0.7 to 2.0)
Ketoprofen	50	8	624	29/141	18/137	21	14	1.6 (0.9 to 2.6)
Ketoprofen	100	5	321	19/86	16/89	22	18	1.2(0.7 to 2.2)
Lornoxicam	8	3	273	84/190	16/70	44	23	1.4 (0.9 to 2.2)
Lumiracoxib	400	4	578	40/307	28/153	13	18	0.7(0.4 to 1.3)
Mefenamic acid	500	2	256	7/53	3/53	13	6	2.2 (0.7 to 7.2)
Naproxen	400/440	3	334	38/173	14/84	22	17	1.3 (0.8 to 2.2)
Naproxen	500/550	9	784	80/291	83/290	27	29	0.96 (0.7 to 1.2)
Oxycodone	5	3	317	48/157	46/160	31	29	1.1 (0.8 to 1.6)
Oxycodone + paracetamol	5/325	3	388	107/221	44/167	48	26	1.6 (1.2 to 2.1)	4.5 (3.2 to 7.9)
Oxycodone + paracetamol	10/650	10	1043	199/343	61/209	58	29	1.8 (1.4 to 2.3)	3.5 (2.7 to 4.8)
Oxycodone + paracetamol	10/1000	2	289	100/147	61/141	68	43	1.6 (1.3 to 2.0)	4.0 (2.8 to 7.3)
Paracetamol	500	6	561	10/158	12/161	7	6	0.9(0.4 to 1.9)
Paracetamol	600/650	19	1886	121/775	102/747	16	14	1.2 (0.9 to 1.5)
Paracetamol	975/1000	28	3232	259/1423	145/919	18	16	1.1 (0.9 to 1.3)
Rofecoxib	50	25	3688	750/2236	409/1168	34	35	0.96 (0.87 to 1.1)