Table 4.
Patterns of GenoType MTBDRplus in comparison to drug susceptibility testing and GeneXpert results
| Number of sputum samples | DST |
MTBDRplus assay |
Results | GeneXpert |
||||
|---|---|---|---|---|---|---|---|---|
| RMP | INH | RMP pattern (rpoB) | INH pattern |
MTB | Rifampin | |||
| katG | inhA | |||||||
| 1 | R | R | ΔWT2,3,4, | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| 1 | S | R | ΔWT7, Mut2B (H526D) | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| 1 | S | S | ΔWT7, Mut2A (H526Y) | ΔWT, Mut1 (S315T) | ΔWT 2, Mut3A (T8C) | MDR | Detected | Resistant |
| 1 | R | R | ΔWT2 | ΔWT, Mut1 (S315T) | ΔWT 2, Mut3A (T8C) | MDR | Detected | Resistant |
| 3 | R | R | ΔWT7 | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| 1 | S | S | ΔWT8, Mut3 (S531L) | WT | WT | Rif monoR | Detected | Resistant |
| 1 | S | S | ΔWT8, Mut3 (S531L) | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| 11 | S | S | ΔWT8 | WT | WT | Rif monoR | Detected | Susceptible |
| 3 | R | R | ΔWT8 | ΔWT, Mut1 (S315T) | ΔWT 2, Mut3B (T8A) | MDR | Detected | Resistant |
| 1 | R | R | ΔWT8 | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| 1 | R | R | ΔWT8 | WT | ΔWT 1, Mut1 (C15T) | MDR | Detected | Resistant |
| 3 | S | S | WT | WT | WT | Susceptible | Detected | Susceptible |
| Detected | Resistant | |||||||
| 2 | R | R | ΔWT3,4, Mut1 (D516V) | ΔWT, Mut1 (S315T) | ΔWT 2, Mut3B (T8A) | MDR | Detected | Resistant |
| 2 | R | R | ΔWT8, Mut3 (S531L) | ΔWT, Mut1 (S315T) | WT | MDR | Detected | Resistant |
| Δ: Absence of hybridization signal with wild-type probes; WT: wild-type; Mut: mutation; DST: drug susceptibility testing; RMP: rifampin; INH: isoniazid; R: resistant; S: susceptible; MDR: multidrug-resistant; Rif monoR: rifampin monoresistant; MTB: M. tuberculosis complex | ||||||||