Table 3.

Results for analyses of mRNA expression of SCN2A alternative transcripts in PFC tissue samples from schizophrenia cases and controls

Group(s)	N	Target for Expression Analysis	Statistical Analysis	F Value	df*	P Value	Cohen’s d	Direction of Effect
Schizophrenia	64	NM_021007	rs10174400 genotype main effect (recessive model)	5.6	1, 60	0.021	0.61	CC>T carriers
Control	61	NM_021007	rs10174400 genotype main effect (recessive model)	2.8	1, 57	0.100	0.44	T carriers>CC
Schizophrenia/Controls	125	NM_021007	Diagnosis main effect	11.0	1. 121	0.001	0.60	Control>Schizophrenia
Schizophrenia/Controls	125	NM_021007	Diagnosis by rs10174400 genotype interaction	7.8	1, 119	0.006	0.38	Opposite
Schizophrenia	64	NM_001040142	rs10174400 genotype main effect (recessive model)	5.0	1, 60	0.029	0.58	CC>T carriers
Control	61	NM_001040142	rs10174400 genotype main effect (recessive model)	0.4	1, 57	0.549	n/a	n/a
Schizophrenia/Controls	125	NM_001040142	Diagnosis main effect	10.7	1. 121	0.001	0.59	Control>Schizophrenia
Schizophrenia/Controls	125	NM_001040142	Diagnosis by rs10174400 genotype interaction	3.8	1, 119	0.054	0.19	Opposite
Schizophrenia	64	NM_001040143	rs10174400 genotype main effect (recessive model)	1.5	1, 60	0.223	n/a	n/a
Control	61	NM_001040143	rs10174400 genotype main effect (recessive model)	2.0	1, 57	0.160	n/a	n/a
Schizophrenia/Controls	125	NM_001040143	Diagnosis main effect	0.1	1. 121	0.750	n/a	n/a
Schizophrenia/Controls	125	NM_001040143	Diagnosis by rs10174400 genotype interaction	0.1	1, 119	0.949	n/a	n/a

N, Number. df, degrees of freedom (* for current effect, after accounting for covariates). Cohen’s d, Standardized mean difference.