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Recognition of DNA damage by AlkD. a, 3d3mA-DNA (substrate) complex; b, THF-DNA (product) complex. Composite omit electron density (contoured to 1σ) for the modified base pairs is superimposed against the crystallographic models. Dashed arrows denote displacement of THF and opposing thymine from their positions in B-DNA. Hydrogen bonds are shown as dashed lines. Views are down the DNA helix axis.
