Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Dev Dyn. 2014 Jul 10;243(9):1055–1066. doi: 10.1002/dvdy.24156

Figure 4.

Figure 4

Neural crest-derived cardiac structures develop normally in Wnt1-CHet and Wnt1-CKO mice. (A) E16.5 embryonic hearts from Wnt1-CHet and Wnt1-CKO embryos exhibited normal septation of the aorta (Ao) and pulmonary trunk (PT) with normal extension of the brachiocephalic (BCA), left common carotid (LCC), and left subclavian (LSA) arteries from the aortic arch. H&E staining of sectioned E16.5 embryonic hearts from Wnt1-Cre conditional heterozygous (B) and Wnt1-CKO (C) mice revealed normal development of the left ventricular outflow tract (LVOT) and inter ventricular septum (IVS). India ink injections of E10.5 Wnt1-Cre conditional heterozygous (CHet) (D) and Wnt1-CKO (E) mice demonstrate normal development of the 3rd, 4th, and 6th pharyngeal arch arteries. Other abbreviations: RA (right atrium); LV (left ventricle); RA (right atrium); LA (left atrium). Lines span lumina of arteries.