. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Dev Dyn. 2014 Jul 10;243(9):1055–1066. doi: 10.1002/dvdy.24156

Table 1.

Foxg1-Cre or Wnt1-Cre conditional loss of Chd7 in mice results in multiple skeletal abnormalities.

Region	Feature	Foxg1-Cre Genotype			Wnt1-Cre Genotype
Region	Feature	Chd7^+/^flox (N=9)	Chd7^Gt/flox (N=6)	CKO (N=7)	Control (N=6)	CKO (N=7)
Cranium	Interocular distance	4.66	4.34	3.72 ^*	5.12	5.01
	Frontal bone dysplasia^†	3	4	7 ^*	0	6 ^*
	Eye dysplasia^†	0	0	7 ^*	0	0
	Intersquamosal distance	6.58	6.38	5.90 ^*	6.23	6.24
	Parietal/interparietal bone dysplasia^†	0	0	0	0	0
	Occipital bone length	3.92	4.10	3.86	3.58	3.47
	Occipital bone dysplasia^†	0	0	0	1	7 ^*
	Rostral-caudal length	9.54	9.27	8.99	9.75	9.46
	Ventral conchae dysplasia^†	0	4 ^*	7 ^*	1	7 ^*
	Dorsal conchae dysplasia^†	0	5 ^*	7 ^*	1	7 ^*
	Palatal shelf dysplasia^†	0	0	7^*	1	7 ^*
	Cleft palate^†	0	0	0	0	3 ^*
	Mandible length	5.29	5.28	5.05	5.55	4.95 ^*
Cervical spine	Atlas (C1) dysplasia^†	0	0	0	0	0
Cervical spine	Axis (C2) dysplasia^†	0	0	0	0	2
Thoracic spine	Rib count	13.0	13.0	12.9	12.9	12.9
Thoracic spine	Rib dysplasia (bifid)^†	1	3	1	2	4
Thorax	Clavicle length	2.49	2.49	2.48	2.60	2.56
Thorax	Tracheal ring count	17.8	19.3	11.0 ^*	16.7	18.9

All measurements are in millimeters.

^†

These observations were scored in a binomial fashion (e.g. dysplasia of the frontal bone was identified as “present” or “absent”). As such, the number of mice affected is scored across each genotype for each observation.

Significance indicated at p < 0.05 relative to Chd7^+/^flox (for Foxg1-Cre) or control(Chd7^+/^flox or Chd7^flox/flox for Wnt1-Cre) by MANOVA with post hoc Tukey's HSD test.