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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Clin Lymphoma Myeloma Leuk. 2013 Jul 26;13(5):515–529. doi: 10.1016/j.clml.2013.03.018

Figure 1.

Figure 1

Schematic Map of Some of the Most Common Amino Acid Substitutions Identified From Clinical Specimens in Patients Resistant to Imatinib. The Stars Highlight Regions Involved in Imatinib Binding. Mutations in Italics Have Been Found to be Single Nucleotide Polymorphismsa

Abbreviations: A loop = activation loop; P loop = phosphate-binding loop; SH2 = SRC homology 2; SH3 = SRC homology 3.

aReproduced with permission of the American Society of Hematology, from Soverini S, et al. Blood 118(5), 2011: 1208–1215,69 permission conveyed through Copyright Clearance Center, Inc.